Asymmetric Synthesis of anti-β-Amino-α-Hydroxy Esters via Dynamic Kinetic Resolution of β-Amino-α-Keto Esters
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چکیده
منابع مشابه
Organocatalytic synthesis of optically active β-branched α-amino esters via asymmetric biomimetic transamination.
This paper describes an efficient asymmetric biomimetic transamination of α-keto esters with a quinine-derived chiral base as the catalyst, giving a variety of β-branched α-amino esters in 50-96% yield and 87-95% ee.
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Biocatalytic procedures can circumvent some of the drawbacks that classical methodologies present in chemical synthesis. One example is shown by the Baeyer-Villiger (BV) reaction, a process discovered more than 100 years ago that consists in the nucleophilic insertion of one atom of oxygen in the adjacent position of a carbonyl moiety affording esters or lactones. This reaction proceeds using p...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2013
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol4009206